Vikrant mahajan biography templates
•
Vikrant Sagoria House no 243
Copyright:
Available Formats
•
Abstract
As a fundamental biological process, DNA replication ensures the accurate copying of genetic information. However, the impact of this process on cellular plasticity in multicellular organisms remains elusive. Here, we find that reducing the level or activity of a replication component, DNA Polymerase α (Polα), facilitates fängelse reprogramming in diverse stem cell systems across species. In Drosophila male and female germline stem fängelse lineages, reducing Polα levels using heterozygotes significantly enhances fertility of both sexes, promoting reproductivity during aging without compromising their longevity. Consistently, in C. elegans the pola heterozygous hermaphrodites exhibit increased fertility without a reduction in lifespan, suggesting that this phenomenon is conserved. Moreover, in male germline and kvinna intestinal stem cell lineages of Drosophila, polα heterozygotes exhibit increased resistance to tissue damage caused bygd genetic ablation or pathogen infect
•