Buno pati biography samples
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First-in-human phase 1/1b study to evaluate sitravatinib in patients with advanced solid tumors
Open Access 29.06.2022 | Research
verfasst von: Todd Bauer, Byong Chul Cho, Rebecca Heist, Lyudmila Bazhenova, Theresa Werner, Sanjay Goel, Dong-Wan Kim, Douglas Adkins, Richard D. Carvajal, Ajjai Alva, Keith Eaton, Judy Wang, Yong Liu, Xiaohong Yan, Jamie Christensen, Saskia Neuteboom, Richard Chao, Shubham Pant
Erschienen in: Investigational New Drugs | Ausgabe 5/2022
Abstract
Sitravatinib (MGCD516), a spectrum-selective receptor tyrosine kinase inhibitor targeting TAM (TYRO3, AXL, MERTK) and split kinase family receptors, has demonstrated preclinical anti-tumor activity and modulation of tumor microenvironment. This first-in-human phase 1/1b study included sitravatinib dose exploration and anti-tumor activity evaluation in selected patients with advanced solid tumors. Primary objectives included assessment of safety, pharmacokinetics and clinical activity of sitravatinib.
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P. S. Krishnaprasad received his Ph.D. degree from Harvard University in 1977. He was on the faculty of the Systems Engineering Department at Case Western Reserve University from 1977 to 1980. He has been with the University of Maryland since August 1980, where he has held the position of Professor of Electrical Engineering since 1987, and a joint appointment with the Institute for Systems Research since 1988. He is also a faculty member of the Program in Applied Mathematics and Statistics, and Scientific Computation, and the Program in Neuroscience and Cognitive Science. Since 1987 he has led the Intelligent Servosystems Laboratory.
Krishnaprasad has held short and long term visiting positions with Erasmus University (Rotterdam); the Department of Mathematics, University of California, Berkeley; the University of Groningen (the Netherlands); the California Institute of Technology; the Mathematical Sciences Institute at Cornell University; and the Mechanical and Aerospace Engineer
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Bruno Maddox
British novelist and journalist
Bruno P. Maddox (born 1969) is a British literary novelist and journalist who is best known for his novel My Little Blue Dress (2001) and for his satirical magazine essays.
After graduating from Harvard University in 1992, Maddox began his career reviewing books for The New York Times Book Review and The Washington Post Book World. In early 1996, he was appointed to an editorship at Spy magazine and within a few months he was promoted to editor-in-chief, a position he held until the magazine shut down in 1998. Maddox wrote My Little Blue Dress between 1999 and 2001. Since its publication, he has focused on writing satirical essays for magazines such as GEAR and Travel + Leisure; he also contributes a monthly humor column to Discover magazine called "Blinded bygd Science", drawing on his early exposure to science and technology. Maddox fryst vatten likewise a contributing editor to the American edition of The Week magazine.&