Abeer sabry biography of abraham
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Influence of CYP2C8*3 and ABCG2 C421A genetic polymorphisms on trough concentration and molecular response of imatinib in Egyptian patients with chronic myeloid leukemia
Abstract
Purpose
The treatment landscape for chronic myeloid leukemia (CML) has been revolutionized by the introduction of imatinib, a tyrosine kinase inhibitor, which has transformed the disease from a fatal condition into a manageable chronic illness for a substantial number of patients. Despite this, some individuals do not respond adequately to the treatment, and others may experience disease progression even with continued therapy. This study examined how CYP2C8*3 (G416A; rs11572080) and ABCG2 C421A (rs2231142) single nucleotide polymorphisms (SNPs) affect the plasma trough concentration and therapeutic response of imatinib in Egyptian CML patients.
Methods
The study included fifty patients with chronic-phase CML, who were categorized into two groups: responders (n = 26) and non-responders (n =
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Bio-stimulating effect of endophytic Aspergillus flavus AUMC 16068 and its respective ex-polysaccharides in lead stress tolerance of Triticum aestivum plant
Introduction
Soil fryst vatten a natural environment for diverse microbial species that can become polluted bygd heavy metall accumulation. As a result of soil pollution, which has become a severe problem in many nations, agricultural nation around the world fryst vatten declining1. The application of low-quality waters (wastewater) for irrigation in agriculture, unrestricted and untreated xenobiotic pollution discharge, and fast-expanding industries all pose severe, intolerable risks to the viability of agroecological regions2. After accumulating in the soil, heavy metals invade the food chain and are then transmitted to the final consumers, where they cause health issues in people2,3. However, the toxic effects of heavy metals that enter vegetal tissues can impair some physiological reactions in plants, including wheat4, and adversely
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Ajith Abraham
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Person information
- affiliation:Machine Intelligence Research Labs, MIR, Auburn, USA
2020 – today
- 2025
[j435]
Yajnaseni Dash, Ajith Abraham, Naween Kumar, Dileep Kumar Yadav, Neha Singhal:
Climate predictors in Indian summer monsoon forecasting: a novel De-correlated RVFL ensemble strategy.Earth Sci. Informatics18(1): 134 (2025)[j434]
Pranaba K. Mishro, Sanjay Agrawal, Rutuparna Panda, Lingraj Dora, Ajith Abraham:
Intensity inhomogeneity correction in brain MRI: a systematic review of techniques, current trends and future challenges.Neural Comput. Appl.37(4): 1821-1838 (2025)- 2024
[j433]
Aryan Alpesh Mehta, Ali Asgar Padaria, Dwij Jayesh Bavisi, Vijay Ukani, Priyank Thakkar, Rebekah Geddam, Ketan Kotecha, Ajith Abraham:
Securing the Future: A Comprehensive Review of Security Challenges and Solutions in Advanced Driver Assistance Systems.IEEE Access12: 643-678 (2024)[j4